12:00-19:00

Registration

15:00-17:30

Council of Physiology Professors      [aula KEPLERO]

15:00-17:30

Young Physiologists meeting     [aula GALILEO]

17:30-18:00

Opening Ceremony     [aula KEPLERO, online connected to GALILEO and LEONARDO]

18:00-19:00

Opening Lecture     [aula KEPLERO, online connected to GALILEO and LEONARDO]

Jocelyne Bloch and Grégoire Courtine (Lausanne, Switzerland)

Spinal cord gateways and restoration of neurological function

19:00

Welcome cocktail

08:30-09:50

Parallel Symposia

S1 • Physiological and prosthetic modulation of visual perception     [aula GALILEO]
Chairs: Patrizia Fattori (Bologna, Italy) & Fabio Benfenati (Genoa, Italy)

Stefano Di Marco (Genoa, Italy)

A molecular photoswitch reactivates the ON/OFF information processing in the dystrophic retina

Elisabetta Colombo (Genoa, Italy)

Photovoltaic nanoparticle actuators and multisensory environmental enrichment for visual restoration and rehabilitation

Annalisa Bosco (Bologna, Italy)

Bridging action and visual perception: neural and behavioral mechanisms across planning and execution phases

Eduardo Fernandez Jover (Alicante, Spain)

Development of a smart bidirectional cortical visual prosthesis for the blind

S2 • The cerebellum in neurodevelopmental disorders: from molecular regulation to circuit dysfunctions     [aula KEPLERO]
Chairs: Eriola Hoxha (Turin, Italy) & Maria Concetta Miniaci (Naples, Italy)

Eriola Hoxha (Turin, Italy)

Early cerebellar circuit alterations in an ATM kinase-dead mouse model

Maria Concetta Miniaci (Naples, Italy)

Structural and functional alterations of cerebellar circuitry following early life stress in mice

Paola Infante (Rome, Italy)

The cerebellar development regulator REN^KCDT11 in autism spectrum disorders

Francesca Prestori (Pavia, Italy)

Cerebellar dysfunction in autism and schizophrenia mouse models: bridging motor and cognitive impairments

S3 • Xenobiotic impacts on placental signaling and fetal development: a critical implication for health     [aula LEONARDO]
Chairs: Maurizio Mandalà (Rende, CS, Italy) & Francesca Ietta (Siena, Italy)

Teresa Tropea (Manchester, United Kingdom)

The Paradox of Maternal Beta-Blockade during pregnancy

Maurizio Mandalà (Rende, CS, Italy)

Impact of bisphenol A on maternal-fetal interface

Francesca Ietta (Siena, Italy)

Endocrine disruptors in pregnancy: impacts on placental function and fetal development

Marco Fiocchetti (Rome, Italy)

Placenta-to-neuron communication under environmental pollution-induced stress

09:50-11:00

Parallel Oral Communications

Cellular and Molecular Physiology     [aula KEPLERO]
Chairs: Tullio Genova (Turin, Italy) & Maria Cristina Filice (Rende, CS, Italy)

Martina Arici (Milan, Italy)

HCN4 misregulation affects the early differentiation process of mouse embryonic stem cells

Daniele Bottai (Milan, Italy)

Movement restraint alters metabolism and oxidative stress in mouse neural stem cells

Giuseppe Calamita (Bari, Italy)

AQP3 and AQP9 play critical but distinct roles in human leukocyte motility

Nicoletta Plotegher (Padua, Italy)

Glucosylated sterols modulate glucocorticoid receptor signalling: implications for the development of neurodegenerative diseases

Aurora Mazzei (Lecce, Italy)

Identification of differential immune cross-talk patterns in macrophage/enterocyte-like monolayer co-cultures based on apical or basolateral LPS exposure

Carla Perego (Milan, Italy)

Unraveling insulin secretion: the role of primary cilia

Neurophysiology (Synaptic and Cognitive Mechanisms)     [aula GALILEO]
Chairs: Eriola Hoxha (Turin, Italy) & Marianna Crispino (Naples, Italy)

Francesca Natale (Rome, Italy)

Intranasal administration of extracellular vesicles derived from neural stem cells ameliorates Alzheimer’s Disease phenotype in 3×Tg-AD mice

Salvatore Fusco (Rome, Italy)

New therapeutic strategies targeting zDHHC enzymes to counteract synaptic and cognitive deficits in Alzheimer's disease

Martina Montanari (Rome, Italy)

Compensatory bioenergetic adaptations and ion channel remodeling in a mouse model of early-onset Parkinson's Disease

Maria Rosaria Tropea (Catania, Italy)

Astrocytic α7 nicotinic receptor dysfunction alters glutamate dynamics and memory flexibility in prodromal Alzheimer’s-like pathology

Marianna Dionisi (Genoa, Italy)

REST/NRSF-mediated regulation of somatic and synaptic calcium homeostasis during neuroinflammation in hippocampal neurons

Simona Denaro (Catania, Italy)

PARP-1 rewires neuroinflammatory and metabolic pathways associated with reactive neuroglia in neuropathic pain

Physiology of Organs and Systems     [aula LEONARDO]
Chairs: Teresa Pasqua (Catanzaro, Italy) & Claudio Molinari (Vercelli, Italy)

Marco Morrone (Sassari, Italy)

Estimating muscle age acceleration by a novel phenotypic clock: cross-sectional study in healthy, middle-aged and older adults

Teresa Pasqua (Catanzaro, Italy)

Catestatin: a key regulator of cardiac physiology that increases metabolic flexibility, improves insulin sensitivity and reshapes mitochondrial function

Andrea Manca (Sassari, Italy)

From V̇O₂max to V̇CO₂max: a sex comparative study on the physiological resilience and durability of endurance athletes

Ilaria Rivolta (Monza, Italy)

A deeper look at the pathophysiological mechanisms of sodium channel dysfunction in Brugada Syndrome

Michal Javorka (Martin, Slovakia)

Genetic variability and cardiovascular autonomic nervous system control

Sergio Delle Monache (Rome, Italy)

Allocentric versus egocentric reference frame in visual and vestibular estimates of motion duration

11:00-12:00

Poster Session 1 and Coffee break (posters must be exhibited also during lunch)

12:00-13:00

Plenary Lecture     [aula KEPLERO, online connected to GALILEO and LEONARDO]

Gerd Heusch (Duisburg-Essen, Germany)

Coronary vascular pathophysiology in myocardial ischemia/reperfusion

13:00-14:30

Lunch

14:30-15:50

Parallel Symposia

S4 • Heart-brain axis: from mechanisms to innovative therapies      [aula KEPLERO]
Chairs: Franca Deriu (Sassari, Italy) & Pasquale Pagliaro (Turin, Italy)

Francesco Moccia (Campobasso, Italy)

Neurovascular unit signaling: endothelial cells integrate neural and physical cues for Ca²⁺-driven NO release

Federica Del Monte (Bologna, Italy)

Amyloid here, Amyloid there, Amyloid everywhere - Alzheimer's Disease Beyond the Brain

Vincenzo Lionetti (Pisa, Italy)

The Role of Cardiac Vagus Nerve Laterality in Regulating Heart Function of Adult Göttingen Minipigs

Francesco Lodola (Milan, Italy)

Light-driven modulation of cellular bioelectricity: A geneless approach

S5 • The Social Animal in action: an integrated perspective on cooperation     [aula GALILEO]
Chairs: Daniele Borzelli (Messina, Italy) & Eros Quarta (Rome, Italy)

Daniele Borzelli (Messina, Italy)

Interpersonal neural synchronization during cooperative force tasks

Arianna Curioni (Vienna, Austria)

Better together? Subjective Utility of Joint Actions.

Eros Quarta (Rome, Italy)

Prefrontal mechanisms subtending decisions to cooperate in non-human primates

Cecilia De Vicariis (Genoa, Italy)

Computational joint action: from joint coordination to artificial partners

S6 • Hypoxia: a multisystem perspective     [aula LEONARDO]
Chair: Giovanni Vinetti (Bolzano, Italy)

Anna Taboni (Brescia, Italy)

Hypoxia as a tool to understand short-term control of blood pressure

Rachel Turner (Bolzano, Italy)

Key mechanistic factors affecting cerebral blood flow during altitude acclimatisation

Christina D. Bruce (Innsbruck, Austria)

The effects of hypoxia on skeletal muscle contractile properties

Danilo Bondi (Chieti, Italy)

Sex-sensitive and insensitive endocrine responses while trekking in the Himalayas

15:50-17:00

Parallel Oral Communications

Neurophysiology (Systems and Molecular)     [aula KEPLERO]
Chairs: Pellegrino Lippiello (Naples, Italy) & Francesca Ginatempo (Sassari, Italy)

Enrica Boda (Orbassano, TO, Italy)

tDCS promotes myelin repair and plasticity in the mouse motor cortex

Mattia Lorenzo Di Francesco (Genoa, Italy)

Ziapin2 as a novel membrane-targeted molecular photoswitch for the inhibition of neuronal hyperexcitability in models of epilepsy, tunable by light stimulation

Pawan Faris (Pavia, Italy)

Dopamine-dependent cerebellar network activity and antipsychotic drug modulation in mice: an ex vivo MEA study

Davide Martelli (Bologna, Italy)

Independent regulation of tumor necrosis factor-α (TNF) and interleukin-10 (IL-10) by splanchnic sympathetic nerves and hypothalamic-pituitary-adrenal axis in response to lipopolysaccharide in rats

Roberta Lorenzi (Pavia, Italy)

Purkinje cells zebrin II pattern shapes large scale brain dynamics

Francesca Ginatempo (Sassari, Italy)

The study of the intricate relationship between sleep and cerebellum in an emotional learning

Physiology of Metabolism and Muscle Physiology     [aula LEONARDO]
Chairs: Carmine Rocca (Rende, CS, Italy) & Sara Petrillo (Turin, Italy)

Carmine Rocca (Rende, CS, Italy)

Metabolic profile and myocardial and coronary dysfunction are improved by Empagliflozin in diabetic and non-diabetic ischemic rat hearts

Monica Dentice (Naples, Italy)

The peripheral effects of Leptin boost energy metabolism in skeletal muscle

Maria Anna Marciano (Naples, Italy)

Long-acting agonist of dopamine counteracts adipose and skeletal muscle lipid accumulation in diet-induced obese rats

Giuliana Panico (Naples, Italy)

Mild calorie restriction induces metabolic adaptation in brown adipose tissue in the short term

Michela Terlizzi (Salerno, Italy)

Sphingosine-1-phosphate is involved in the physiological metabolic reprogramming of fibroblasts during hypoxia

Sara Petrillo (Turin, Italy)

Heme and lipid metabolic interplay during angiogenesis

Environmental and Muscle Physiology     [aula GALILEO]
Chairs: Silvestro Roatta (Turin, Italy) & Federico Alessandro Ruffinatti (Turin, Italy)

Silvestro Roatta (Turin, Italy)

Lower body negative pressure as a countermeasure to the venous congestion induced by simulated microgravity

Giulia Terribile (Monza, Italy)

The impact of air pollution on brain physiology: addressing challenges and providing solutions

Elisabetta Piva (Padua, Italy)

Sequential antioxidant and immune regulation in T. bernacchii during simulated marine heatwaves

Beatrice Maspes (Brescia, Italy)

Mechanical efficiency of lower limb eccentric cycling

Rosita Rabbito (Turin, Italy)

Towards spatial mapping of dynamic cerebral autoregulation using functional near-infrared spectroscopy (fNIRS)

Daniele Pensabene (Cassino, Italy)

p75NTR modulation restores redox disbalance and metabolic aberrations in a cellular model of Parkinson’s disease

17:00-18:00

Poster Session 2 and Coffee break (posters must be exhibited until 9.50 of the following day)

18:00-19:00

pH Lecture     [aula KEPLERO, online connected to GALILEO and LEONARDO]

Telmo Pievani (Padua, Italy)

SERENDIPITY. Expecting the unexpected in science

08:30-09:50

Parallel Symposia

S7 • Innovative cancer physiology insights: cell mechanisms & microenvironment interactions– Joint Symposium of Slovenian-Italian Physiological Societies     [aula KEPLERO]
Chairs: Alessandra Fiorio Pla (Turin, Italy) & Jernej Jorgačevski (Ljubljana, Slovenia)

Maja Potokar (Ljubljana, Slovenia)

Plectin in Glioblastoma: From Potential Biomarker to Therapeutic Target

Giorgia Chinigò (Turin, Italy)

Crosstalk between tumor microenvironmental acidosis and Ca²⁺ channels in pancreatic ductal adenocarcinoma progression

Jernej Jorgačevski (Ljubljana, Slovenia)

Autophagy in Astrocyte-Mediated Flavivirus Neurotropism

Luigi Catacuzzeno (Perugia, Italy)

Piezo1 Mechanosensitive Channels Control Volume and Shape of Human Glioblastoma Cells

S8 • Glial physiology and biophysics: from sensing and modulation to neuroinflammatory and computational dynamics     [aula GALILEO]
Chair: Grazia Paola Nicchia (Bari, Italy)

Antonio Cibelli (Bari, Italy)

Fluid-induced sensing in astrocytes under shear and osmotic stress

Francesca Massenzio (Bologna, Italy)

Unveiling glial physiology: microRNAs and vesicle-bsed communication in neuroinflammation

Valentina Benfenati (Bologna, Italy)

Glial Engineering: stimulation and monitoring of astrocytes through materials, devices and light

Wolfgang Losert (College Park, USA)

Harnessing astrocyte biophysics for neural network intelligence

S9 • Environmental physiology of aquatic organisms in a changing world     [aula LEONARDO]
Chairs: Laura Canesi (Genoa, Italy) & Elena Fabbri (Bologna, Italy)

Felix Mark (Bremerhaven, Germany)

A plea for cell physiology

Maria Cristina Filice (Rende, CS, Italy)

Mechanisms of hypoxia adaptation in fish: from tissue to mitochondria

Federica Impellitteri (Messina, Italy)

Understanding physiological mechanisms in freshwater mollusks: the role of calcium and bicarbonate in Lymnaea stagnalis

Teresa Balbi (Genoa, Italy)

Multiple mechanisms of action of the antidepressant fluoxetine in non target aquatic species: the mussel Mytilus galloprovincialis as a case study

09:50-11:00

Parallel Oral Communications

Neurophysiology (Development and Modeling)     [aula KEPLERO]
Chairs: Andrea Marcantoni (Turin, Italy) & Francesca Montarolo (Orbassano, TO, Italy)

Diletta Capobianco (Bari, Italy)

Tunneling nanotubes and extracellular vesicles enable intercellular transfer of a master regulator of human neural stem cell fate: a new mechanism for neurogenesis regulation?

Luca Maragliano (Ancona, Italy)

Atomistic simulations of ion channel function in health and disease

Matteo Spinelli (Sassari, Italy)

Anodal transcranial stimulation orchestrates divergent neuronal and astrocytic responses: uncovering cellular pathways

Caterina Michetti (Genoa, Italy)

Social regression in a mouse model of autism stems from a latent phase of gabaergic dysfunction and sensory breakdown

Onofrio Valente (Bari, Italy)

Regulation of AQP4 during brain development and aging by antisense lncRNAs

Darin Zerti (L'Aquila, Italy)

Irisin enhances retinal pigment epithelium homeostasis by Integrin receptor as a potential therapeutic target for Age-related Macular Degeneration

Cellular and Molecular Physiology (II)     [aula GALILEO]
Chairs: Maria Pia Gallo (Turin, Italy) & Andrea Gerbino (Bari, Italy)

Alessio Canovai (Pisa, Italy)

Astrocyte-mediated protection of the hypoxic retina: exploring the functional role of β3-adrenoceptors

Roberta De Zio (Bari, Italy)

BiPOLES for bidirectional optogenetic control of cardiomyocytes and non-myocytes

Andrea Gerbino (Bari, Italy)

Turning mitochondria into a clustered network: a new tool to probe endoplasmic reticulum–mitochondria crosstalk in mammalian cells

Elena Battirossi (Sesto Fiorentino, Italy)

Dynamic remodelling of the neuronal cytoskeleton by mutations in β- and γ-actin isoforms leading to Non-Muscle Actinopathies (NMAs)

Alberto Melecchi (Pisa, Italy)

Thyroid hormone-mediated adaptation to hyperglycemic stress: new evidence from the retina

Giorgia Scarpellino (Pavia, Italy)

The mechanosensitive Piezo1 channels as emerging regulators of brain microvascular homeostasis

Mixed (Neurophysiology and Systems Physiology)     [aula LEONARDO]
Chairs: Saveria Femminò (Orbassano, TO, Italy) & Andrea Moriondo (Varese, Italy)

Andrea Moriondo (Varese, Italy)

The paradox of intraluminal valves in lymph progression: a helpful hindrance to flow

Mariangela Centrone (Bari, Italy)

The Brain-Kidney crosstalk in microgravity

Marco Rinaudo (Rome, Italy)

Leptin receptor lactylation links psychophysical stress to energy balance regulation

Alessandro Silvani (Bologna, Italy)

The motor fingerprint of nighttime sleep and wakefulness and its autonomic cardiovascular correlates

Eduardo Penna (Naples, Italy)

Extracellular vesicles as a novel therapeutic strategy for Angelman syndrome by modulation of synaptic plasticity, dendritic spine density, and cognitive outcomes

Melania Melis (Monserrato (CA), Italy)

Genetic and epigenetic effects on the taste buds' trophic factor, Gustin salivary protein

11:00-12:00

Poster Session 3 and Coffee break (posters must be exhibited also during lunch)

12:00-13:00

Herlitzka Lecture     [aula KEPLERO, online connected to GALILEO and LEONARDO]

Manuela Zaccolo (Oxford, United Kingdom)

Signalling at the nanoscale: cAMP compartmentation by phosphodiesterases

13:00-14:30

Lunch

14:30-15:30

Ruzzier Lecture     [aula KEPLERO, online connected to GALILEO and LEONARDO]

Emilio Carbone (Turin, Italy)

From action potential to atomic structure of ion channels: 73 years of voltage-clamp

15:30-16:00

Coffee break

16:00-19:00

SIF General Assembly     [aula KEPLERO, online connected to GALILEO and LEONARDO]

20:00

Social dinner

The three poster sessions are scheduled for Thursday, 18 September, from 11:00 to 12:00 and during lunch (PS1), from 17:00 to 18:00 (PS2) and for Friday, 19 September, from 11:00-12:00 and during lunch (PS3).

Poster presenters are required to be available for discussion during their assigned session.

• Poster Session 1 Session 1 1
• Poster Session 2 Session 2 2
• Poster Session 3 Session 3 3

• Poster Session 1 • 18 September
  11:00-12:00 and lunch 13:00-14:30

  Cellular and Molecular Physiology

  P1.1 Marilena Ardone (Bari)
  circBFAR promotes pancreatic cancer malignancy through increased tumor parenchymal cell invasion and cancer stem cell-induced chemoresistance
  
  P1.2 Rosanna Avola (Enna)
  Apoptosis induction of the Fabiana imbricata Ruiz & Pav essential oil in prostate cancer cells
  
  P1.3 Volodymyr Balatskyi (Warsaw, Poland)
  Role of stearoyl-CoA desaturase 1 in the regulation of mouse cardiomyocyte maturation
  
  P1.4 Amilcare Barca (Lecce)
  The SLC15A5 peptide/histidine transporter: portrait of an atypical solute carrier from a dark gene compared to the enlightened SLC15 family members
  
  P1.5 Massimo Bardotti (Siena)
  Metabolic reprogramming of activated-dendritic cells exposed to hypoxia
  
  P1.6 Daniele Benedetti (Milan)
  T78K Caveolin-3 Mutation in the cardiomyocytes preserved trafficking of ion channels but altered electrophysiological properties and contractile kinetics.
  
  P1.7 Francesca Bianco (Turin)
  Orai1 role in Br-SQ-C4 induced Ca²⁺ dynamics in PDAC phototoxicity
  
  P1.8 Elena Bossi (Varese)
  Disrupted GABA transport: how SLC6A1 variants affect GAT1 function and neurodevelopment
  
  P1.9 Arianna Brovero (Orbassano, TO)
  Cardioprotective effects of empagliflozin against lipid-induced cellular stress in H9c2 cells
  
  P1.10 Serena Canzolino (Milan)
  Interleukin-6: a key modulator of cardiac nodal cells physiology
  
  P1.11 Sara Caputo (Rome)
  Investigating the role of neuroglobin in lipid metabolism: a spotlight on cholesterol in neuron-derived cells
  
  P1.12 Rosa Cardone (Bari)
  Microenvironmental acidosis drives normal pancreatic branching morphogenesis and tumor vasculogenic mimicry (VM) via opposite roles of the Na⁺/H⁺ Exchanger isoform 1 (NHE1)
  
  P1.13 Valentina Cerrato (Turin)
  A single cell atlas to unveil the diversity of mouse cerebellar astrocytes: insights into their molecular identities, development, and functions
  
  P1.14 Rosa Ciullo (Orbassano, TO)
  Uncovering Takotsubo pathophysiology through extracellular vesicle profiling
  
  P1.15 Claudia Colussi (Rome)
  Chronic mild stress impairs HDAC4 dependent neuronal regulation in the nucleus accumbens: implications for glutamatergic synaptic transmission
  
  P1.16 Federica Coppola (Siena)
  Sequestosome-1/p62 ZZ-domain is involved in toll-like receptor 4 singling in human dendritic cells under normoxic and hypoxic conditions.
  
  P1.17 Chiara Coppola (Lecce)
  Dissecting the physiological and pathological roles of miRNAs in ischemic heart
  disease: a comparative analysis of plasma, pericardial and pleural fluids
  
  P1.18 Anna De Bartolo (Rende, CS)
  Selenoprotein T as a novel regulator of cardiomyocyte senescence: pivotal role of the CD36 Receptor
  
  P1.19 Francesca De Palma (Pozzuoli)
  Beneficial anti-inflammatory effects of oat-based postbiotics derived either from fermentation in capsule mini bioreactor and fermentation with free cells
  
  P1.20 Lorenza Di Marsico (Pisa)
  Exploring early neurodegenerative phenomena in amyotrophic lateral sclerosis: insights from the SOD1^G93A mouse model.
  
  P1.21 Francesco Di Palma (Bari)
  Tunneling Nanotubes-Mediated Transmitophagy Supports Glioma Survival in Hypoxic Niches
  
  P1.22 Irene Filippi (Siena)
  Hypoxia-driven metabolic reprogramming in myeloid lineages: role of Hedgehog signaling
  
  P1.23 Paolo Flace (Bari)
  An immunohistochemical study on calretinin immunorective non-traditional large neuron types in the granular layer of the human cerebellar cortex
  
  P1.24 Stefania Fulle (Chieti)
  Effect of cross-talk by extracellular vesicles derived from human Myogenic Precursor Cells on human Bone Marrow Mesenchymal Stem Cells
  
  P1.25 Alessandra Galli (Milan)
  New insights into insulin signalling in the brain: role of LRRK2 kinase activity in the regulation of insulin receptor trafficking in microglia
  
  P1.26 Nicoletta Garofalo (Rome)
  High fat diet reduces hippocampal dendritic spine density by altering S-palmitoylation of synaptic proteins.
  
  P1.27 Paola Gavazzo (Genoa)
  Age-related hearing loss: the role of KIR4.1 and protective effect of quercetin
  
  P1.28 Patrizia Gena (Bari)
  NB4 cell line as a human-derived model to study the Aquaporin-9 (AQP9) involvement and regulation in neutrophil physiology and pathophysiology
  
  P1.29 Anna Gervasi (Catania)
  Mitochondrial translocation of connexin 43 and modulation of metabolic homeostasis in human glioma cell lines
  
  

  Neurophysiology

  P1.30 Natalia Abate (Naples)
  Deciphering the role of CSTB–TRiC/CCT complex disruption in the pathogenesis of EPM1
  
  P1.31 Pasqua Abbrescia (Bari)
  Patient-derived EVs and iPSCs as a personalized platform for modeling autism spectrum disorders
  
  P1.32 Giuseppe Aceto (Rome)
  mGlyR activation enhances glutamatergic transmission in the medium spiny neurons of the nucleus accumbens
  
  P1.33 Luca Alberti (Bologna)
  Cardiovascular responses to different blood components in a rat model of subarachnoid hemorrhage
  
  P1.34 Anthony Battaglia (Turin)
  Effects of Exogenous α-Synuclein oligomers on synaptic activity and calcium dynamics in cultured dopaminergic and hippocampal neurons
  
  P1.35 Alberto Bernacchi (Bologna)
  Clove bud essential oil ameliorates symptoms and improves survival in SOD1-G93A murine Amyotrophic Lateral Sclerosis models
  
  P1.36 Olga Teresa Bianciotto (Turin)
  Enhancing human cerebellar organoids with enrichment of region-specific glia
  
  P1.37 Roberto Bonanni (L'Aquila)
  Activation of ERRs prevents glutamate-induced neuronal death in differentiated HT22 cells
  
  P1.38 Emiliano Brunamonti (Rome)
  A drift diffusion modeling approach reveals differences in decision-making dynamics across species and age
  
  P1.39 Serena Calamaio (Monza)
  Modeling cortical development and activity in vitro using human iPSCs and primary neurons
  
  P1.40 Chiara Cambini (Turin)
  Chelating Nanobubbles Counteract Amyloid-β-Induced Functional Impairment in Cultured Hippocampal Networks
  
  P1.41 Caterina Canevari (Genoa)
  Synapsin II silencing reveals calcium-dependent regulation of excitatory synaptic function
  
  P1.42 Antonino Casile (Messina)
  EEG responses during the observation of live actions, filmed actions and avatars
  
  P1.43 Viviana Cavallo (Lecce)
  The PKA-AMPK axis regulates autophagy and neuroinflammation in an astroglia cell model
  
  P1.44 Giada Cellot (Trieste)
  Aging tunes social preference and the response to social deprivation in zebrafish
  
  P1.45 Marta Cerina (Milan)
  β2-containing neuronal nicotinic receptors (nAChRs) regulate glutamatergic synapse formation in neocortex, implications for sleep-related epilepsy
  
  P1.46 Felice Cicciarelli (Turin)
  Unraveling the role of emotional memory in anxiety-related behaviors in rats
  
  P1.47 Mayra Colardo (Pesche, IS)
  Neuroglobin orchestrates cholesterol metabolism in an astrocyte-derived cell line
  
  P1.48 Maria Conforti (Pavia)
  Age-dependent dysfunction of inhibition in the mPFC of the IB2 KO mouse model of autism
  
  P1.49 Marianna Crispino (Naples)
  Synaptic protein synthesis as key molecular mechanism in brain plasticity
  
  P1.50 Maria Erika D'Alessandro (Catanzaro)
  Multi-electrode array (MEA) analysis of hiPSC-derived dopaminergic neurons from patients affected by sporadic Parkinson disease: preliminary data
  
  P1.51 Riccardo Dalla Volta (Milan)
  Enduring suppression of corticospinal excitability when observing pictures of hand actions
  
  P1.52 Marina Damato (Lecce)
  Specific matrisome profiles mediate regeneration in peripheral nerves
  
  P1.53 Antonio De Iure (Rome)
  Role of misfolded α-synuclein in the early and advanced stages of neurodegeneration in in vitro and ex vivo Parkinson's disease models
  
  P1.54 Maria Egle De Stefano (Rome)
  Neurochemical imbalances in the mdx mouse hippocampus: potential contribution of D-aspartate and D/L-amino acids alterations in Duchenne Muscular Dystrophy
  
  P1.55 Franca Deriu (Sassari)
  The role of the sensorimotor integration in dynamic face expression processing: a TMS study
  
  P1.56 Fabio Di Bello (Rome)
  Motivational sharpening of spatial attention and motor control interaction: insights from the dorsal premotor cortex of the monkey
  
  P1.57 Francesco Ercolino (Pavia)
  Cerebellar TMS in ataxia: sensorimotor learning and circuit recordings in tottering mice
  
  P1.58 Giuditta Gambino (Palermo)
  Cognition at the core: reconceptualizing metabolic syndrome through neuro-metabolic convergence
  
  P1.59 Marta Gaviraghi (Pavia)
  Specific structural and functional alterations in the somatomotor and attentional networks differentiate Joubert Syndrome from slow progressive ataxia
  
  P1.60 Giuseppe Giglia (Palermo)
  Is opuntia ficus indica able to modulate cortical excitability outside the motor strip? A NIBS study on executive functions
  
  P1.61 Camilla Giglio (Turin)
  Decoding the neural mechanisms linking emotion and social behavior in Autism Spectrum Disorder
  
  P1.62 Raffaella Grimaldi (Genoa)
  Exploring the Role of REST in the Regulation of Gamma Oscillations through GABAergic Circuit Modulation
  
  P1.63 Lorenzo Guidotti (Pisa)
  Acebuche olive oil exerts a protective effect on the pial microcirculation by attenuating the molecular alterations in a murine model of Alzheimer’s disease
  
  P1.64 Md. Tanbeer Haque (Rome)
  Pupillary dilations in response control across contexts
  
  

  Physiology of Metabolism

  P1.65 Sara Baldassano (Palermo)
  Selenium-biofortified strawberries: impact on glucose and hepatic homeostasis modulation in healthy adults – a 30-day randomized controlled trial
  
  P1.66 Pasquale Calvi (Palermo)
  Protective role of kumquat chronic ingestion in liver homeostasis through microbiota modulation
  
  P1.67 Luisa Cigliano (Naples)
  GuT-brain axis dysfunction induced by fructose is prevented by Bacillus spores through neuroprotective secondary bile acids
  
  P1.68 Fabiano Cimmino (Naples)
  Oleoylethanolamide fights obesity by boosting metabolic flexibility, mitochondrial health, and gut microbiota modulation
  
  P1.69 Andrea Foppiani (Milan)
  Interplay of Insulin Sensitivity, Clearance, and β-cell Glucose Sensitivity in Glucose Tolerance
  
  P1.70 Rachele Garella (Florence)
  Influence of growth differentiation factor 15 (GDF15) on the gastric smooth muscle from rodents: a morpho-functional study
  
  P1.71 Federica Geddo (Turin)
  S-allyl cysteine attenuates palmitic acid-induced insulin resistance in C2C12 myotubes through a direct modulation of the insulin receptor
  
  P1.72 Tadeja Jakus (Izola, Slovenia)
  Fat taste perception and preference in overweight and obese children
  
  P1.73 Chiara Rubeo (Orbassano, TO)
  The role of RSK in sepsis-induced systemic inflammation and cardiac injury
  
  

• Poster Session 2 • 18 September
  17:00-18:00

  Environmental Physiology

  P2.1 Manon Auguste (Genoa)
  Immune responses to multiple challenge with different bacterial isolates can reveal the dynamics of host-pathogen interactions in marine bivalves
  
  P2.2 Caterina Barilari (Brescia)
  Arterial baroreflex responses at breath-hold start in air and water: effect of face immersion
  
  P2.3 Alessia Caferro (Rende, CS)
  The antihypertensive Valsartan influences the cardiac function of the goldfish Carassius auratus.
  
  P2.4 Rita Canella (Ferrara)
  Ozone and lung epithelium: dissecting the mechanism of potassium current modulation
  
  P2.5 Laura Canesi (Genoa)
  Biomonitoring growth and physiological conditions of aquacultured gilthead seabream Sparus aurata and seabass Dicentrarchus labrax
  
  P2.6 Marika Cordaro (Messina)
  Physiological and neurobehavioral dysregulation induced by isothiazolinone: role of oxidative stress and apoptosis
  
  P2.7 Cinzia Del Gaudio (Siena)
  Environmental pollutants compromise early placentation: a cellular insight
  
  P2.8 Elena Fabbri (Bologna)
  Pharmaceuticals as environmental contaminants: addressing the mechanisms of action in marine bivalves
  
  P2.9 Alfonsina Gattuso (Rende, CS)
  The health of marine sentinels under tourism pressure: a biomarker-based evidence
  
  P2.10 Eugenio Geremia (Naples)
  Adaptation mechanisms of new early warning bioindicator of climate change, the Invasive Alien Species Pinctada radiata
  
  P2.11 Maria Giordano (Lecce)
  Impact of environmentally relevant PET (polyethylene terephthalate) nanoplastics on fibroblasts: insights from NHI-3T3 cells
  
  P2.12 Shaghayegh Kholdihaghighi (Padua)
  Effects of Environmental Pollutants on the Antioxidant Physiological Responses of the Antarctic Scallop Adamussium colbecki
  
  P2.13 Martina Leonessi (Genoa)
  Seasonal variations in immunocompetence of Mytilus galloprovincialis and its specificity towards different bacteria
  
  P2.14 Maria Giulia Lionetto (Lecce)
  Impact of colchicine, a pharmaceutical pollutant, on hemocyte motility in Mytilus galloprovincialis
  
  P2.15 Maria Carolina Martone (Naples)
  Assessing physiological markers of environmental stress in Mytilus galloprovincialis farmed in the Gulf of Pozzuoli
  
  P2.16 Cristiana Multisanti (Messina)
  Discovering isothiazolinones: comparison of the effects of octylisothiazolinone and methylisothiazolinone on physiological parameters in a marine model organism
  
  P2.17 Sara Pacchini (Padua)
  The new generation PFAS Gen-X modulates antioxidant enzyme activity in Procambarus clarkii in response to oxidative stress risk
  
  P2.18 Gianfranco Santovito (Padua)
  Stress granules as post-transcriptional regulators of antioxidant defences under PFAS exposure in Squalius cephalus.
  
  P2.19 Renato Spigarelli (Bologna)
  Intestinal uptake of microplastics: In vitro evidence from intestinal epithelial cells
  
  P2.20 Paola Valbonesi (Ravenna)
  Serotoninergic system characterization in the Mediterranean mussel, Mytilus galloprovincialis
  
  P2.21 Maria Grazia Zizzo (Palermo)
  Impact of chronic low-dose exposure to mixtures of Sicilian environmental pollutants on gut integrity and inflammation risk
  
  

  Muscle Physiology

  P2.22 Riccardo Borzuola (Rome)
  Neuromuscular adaptations to whole-body neuromuscular electrical stimulation in elderly with and without sarcopenia
  
  P2.23 Imma Ceriello (Rome)
  Intermuscular coherence in plantar- and dorsiflexor muscles during standing reaching tasks
  
  P2.24 Mihaela Jurdana (Izola, Slovenia)
  The role of the body shape index (ABSI) in the assessment of muscle strength and function in older adult haemodialysis patients
  
  P2.25 Giusy Pietrafesa (Potenza)
  Beta-1 blockade reduces oxidative stress and enhances cell survival during cardioplegia and hypoxia in HL-1 cardiomyocytes
  
  P2.26 Massimo Reconditi (Sesto Fiorentino)
  Temporal relation between titin stiffening upon stimulation of skeletal muscle and X-ray signals marking  thin and thick filament  activation
  
  

  Physiology of Organs and Systems

  P2.27 Tommaso Angelone (Rende, CS)
  Dynamic changes in Selenoprotein T levels reflect cardiovascular disease severity in humans: insights into a novel cardioprotective biomarker
  
  P2.28 Marta Borrelli (Milan)
  Exhaustion time during sinusoidal exercise is reduced in young, physically active smokers
  
  P2.29 Kashi Brunetti (Viterbo)
  Drosophila melanogaster as a model for drug candidates and nutraceuticals targeting inflammatory bowel disease
  
  P2.30 Martina Coletta (Fisciano, SA)
  Caloric restriction modulates mitochondrial dynamic machinery in rat liver
  
  P2.31 Milena Esposito (Rende, CS)
  Effect of extra virgin olive oil on a rat preeclamptic model
  
  P2.32 Arianna Mazzoli (Naples)
  White adipose tissue browning as protecting strategy induced by Bacillus subtilis spores administration in preventing the metabolic dysregulation induced by 6 weeks of high fructose diet in young rats
  
  P2.33 Claudio Molinari (Vercelli)
  AI-based predictive modeling of heart rate variability dynamics over time
  
  P2.34 Federica Pessina (Siena)
  Effects of Bisphenol A on the viability and intracellular calcium in human vascular smooth muscle cells
  
  P2.35 Cristian Poletto (Verona)
  Mapping the brain: the neural bases of sign-tracking and goal-tracking behaviour
  
  P2.36 Marco Romanelli (Turin)
  Venous pulse wave velocity is a sensitive marker of blood volume shifts
  
  P2.37 Rossana Scuri (Pisa)
  Effects of N3SA analogues on cerebral and peripheral arteriolar vasomotion in spontaneously hypertensive rats
  
  P2.38 Eleonora Solari (Varese)
  RNaseT2-induced modulation of the pacemaker activity in rat diaphragmatic lymphatics: functional insights
  
  P2.39 Jorge Storniolo (Meda)
  Relationships between phase-specific heart rate variability derived indices and peak power output during incremental exercise tests in amateur athletes
  
  P2.40 Zuzana Turianikova (Martin, Slovakia)
  Breathing pattern and its variability in Parkinson's disease
  
  

• Poster Session 3 • 19 September
  11:00-12:00 and lunch 13:00-14:30

  Cellular and Molecular Physiology

  P3.1 Magalì Giordano (Orbassano, TO)
  Modulatory role of platelets in ischemia/reperfusion injury: functional impact of ADP and NLRP3 inhibition
  
  P3.2 Sandra Imbrogno (Rende, CS)
  Functional expression of the immune/inflammation related SLC15A4/PHT1 transporter in the zebrafish teleost model
  
  P3.3 Maria Vittoria Leonardi (Perugia)
  Selectivity Filter diameter and possible role in single-channel conductance in potassium ion channels
  
  P3.4 Raffaella Liuni (Salzburg, Austria)
  Novel pathophysiological mechanisms in sensorineural hearing loss with enlarged vestibular aqueduct
  
  P3.5 Michele Maffia (Lecce)
  Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease
  
  P3.6 Rosanna Mallamaci (Bari)
  New insights into the activity of Anle138b from in vitro models of Parkinson’s disease
  
  P3.7 Daniele Mancardi (Orbassano, TO)
  Differential role of autoimmune serum on the angiogenic activity of venous and microcirculatory endothelial cells
  
  P3.8 Giuliana Mannino (Enna)
  In vitro strategies for neural differentiation of human adipose-derived mesenchymal stem cells
  
  P3.9 Beatrice Mantuano (Orbassano, TO)
  A synthetic avenanthramide modulates key functional properties of H9c2 cardiomyoblasts
  
  P3.10 Simona Martinotti (Alessandria)
  Honey's sweet touch: unveiling the honey effects on osteoblast physiology
  
  P3.11 Stefano Masoli (Pavia)
  Biophysically realistic computational models of an inferior olive neuron and its synaptic activity on human and mouse Purkinje cells spines.
  
  P3.12 Alessia Memeo (Bari)
  S-Palmitoylation dependence of AQP4-M1 tetramers dynamics
  
  P3.13 Sara Monaci (Siena)
  Hypoxia-driven regulation of dendritic cells via the Hippo signaling pathway
  
  P3.14 Anna Palmiero (Naples)
  A novel functional role of a nutraceutical formulation in modulating oxidative stress and inflammation in human hepatocyte-like HepG2 cells and clinical implications
  
  P3.15 Giuseppe Petito (Caserta)
  Mitochondrial functionality in Amyotrophic Lateral Sclerosis Linked to TDP-43 p.G376D Mutation
  
  P3.16 Marianna Ranieri (Bari)
  p-Coumaric acid as a possible novel positive Calcium-Sensing Receptor modulator impairing the vasopressin-induced water reabsorption
  
  P3.17 Giulia Rossi (Rome)
  Inflammatory pathway in neurons as driver of cell degeneration under mutant huntingtin expression
  
  P3.18 Gianluca Rovito (Lecce)
  Valutazione degli effetti antitumorali del complesso monofunzionale cationico Pt(II) [Pt(1-esil-1H-imidazolo)(η₁-C₂H₄OEt)(phen)]Cl sulla linea cellulare di cancro pancreatico chemioresistente
  
  P3.19 Federico Alessandro Ruffinatti (Turin)
  Profiling the expression of the transportome in cancer by a systematic approach
  
  P3.20 Elena Savio (Turin)
  Impact of breast cancer conditioning on endothelial purinergic signaling
  
  P3.21 Benedetta Spedicato (Lecce)
  Physiological role of short-chain fatty acids in modulating inflammatory pathways in skin diseases
  
  P3.22 Arianna Sturlese Verduri (Pisa)
  Agonism approach to unveiling the role of Beta 3 adrenoceptor in human glioblastoma: friend or foe?
  
  P3.23 Filippo Torrisi (Catania)
  Hypoxia-induced metabolic adaptations in glioma based on isocitrate dehydrogenase mutation status
  
  P3.24 Giovanna Traina (Perugia)
  Microbial cell-free supernatants exhibited anti- or pro-inflammatory activity on human epithelial cells
  
  P3.25 Paola Maura Tricarico (Trieste)
  Aquaporin-3 as a new player in the pathophysiology of hidradenitis suppurativa
  
  P3.26 Chiara Vaghi (Turin)
  Pancreatic ductal adenocarcinoma progression: a complex crosstalk between tumor microenvironmental stiffness and Ca²⁺ channels
  
  P3.27 Giovanna Valenti (Bari)
  Dual treatment with metformin and cinacalcet significantly reduces cyst growth of human 3D cells derived from ADPKD cyst-lining epithelia and restores the altered bioenergetic profile
  
  P3.28 Daniele Vergara (Lecce)
  PKC induces senescence via p53 and NDRG1 signalling
  
  P3.29 Giulia Vergine (Lecce)
  Biological activity of an alcoholic walnut husk extract in human keratinocytes
  
  

  Neurophysiology

  P3.30 Timna Hitrec (Bologna)
  The neural pathways underlying torpor and arousal in mice
  
  P3.31 Edoardo Lecce (Rome)
  The accuracy of steady force is controlled by the integrated modulation of common synaptic input and neuromechanical delay in humans
  
  P3.32 Ninfa Liccardi (Genoa)
  REST/NRSF Regulates Synaptic plasticity Through Selective Modulation of NMDARs
  
  P3.33 Dmitry Lim (Novara)
  Role of astroglial calcineurin in Alzheimer's disease
  
  P3.34 Alessandra Lodi (Orbassano, TO)
  Sex differences in susceptibility to audiogenic seizures and cardiac arrhythmias in GluN2A(N615S) mice   
  
  P3.35 Martina Lorenzati (Orbassano, TO)
  Modeling Autosomal Dominant LeukoDystrophy (ADLD) pathology with human iPSC-derived glial cells: altered phenotypes and rescue strategies
  
  P3.36 Jose Maya-Vetencourt (Pisa)
  Anti-inflammatory-antioxidant nanoparticles: a novel nanotechnological therapy for neurodegenerative blindness
  
  P3.37 Giacomo Mazzoni (Genoa)
  Nav1.6 as a key effector of PRRT2-linked cerebellar dysfunction
  
  P3.38 Tasnim Mohamed (Milan)
  Mitochondrial dynamic and epigenetic changes in Schwann cells following electromagnetic field exposure
  
  P3.39 Francesca Montarolo (Orbassano, TO)
  Neurodegeneration and white matter defects in a neuron-specific Atm kinase-dead murine model of Ataxia-Telangiectasia
  
  P3.40 Lala Chaimae Naciri (Monserrato (CA))
  Automatic detection of fungiform papillae on the human tongue via convolutional neural networks
  
  P3.41 Ida Nifo Sarrapochiello (Rome)
  Long-term exposure to low doses of benzene affects brain functions by inducing alterations of neuroplasticity-related molecular mechanisms
  
  P3.42 Eleonora Pali (Pavia)
  Altered cerebellar Purkinje cell excitability and synaptic transmission in the IB2 KO mouse model of autism
  
  P3.43 Sofia Passaponti (Siena)
  Urinary small extracellular vesiscles differentially modulate nociceptive signaling
  
  P3.44 Roberto Piacentini (Rome)
  Lithiated gold nanoparticles as promising therapy for Alzheimer's disease
  
  P3.45 Ricardo Piña (Santiago, Chile)
  The dysregulation of TRPM8 and Kv1 channels contributes to the development of cold allodynia following trigeminal nerve injury in a murine model
  
  P3.46 Maria Vittoria Podda (Rome)
  Altered brain connectivity and neuron-specific intracellular translocation of extracellular matrix proteases as earlier pathological signatures in an Alzheimer's disease-like mouse model
  
  P3.47 Eleonora Poeta (Bologna)
  Modeling Angelman Syndrome using patient-derived hiPSCs: toward a comprehensive in vitro disease model
  
  P3.48 Edoardo Porzano (Genoa)
  Enhancing visual restoration in Retinitis pigmentosa: synergistic effects of environmental enrichment and P3HT nanoparticles
  
  P3.49 Francesca Proto (San Giovanni Rotondo, FG)
  Pathogenic E69K-GFAP variant disrupts filament assembly and mitochondrial dynamics in human astrocytes: a cellular model of Alexander Disease
  
  P3.50 Tiziana Ravasenga (Novara)
  ATM drives excitability maturation in human neural progenitor cells
  
  P3.51 Michela Redana (Turin)
  Rethinking neurotransmitter release: the role of ryanodine receptor–dependent calcium signalling in central neurons
  
  P3.52 Marta Ribodino (Turin)
  Functional integration and circuit reconstruction by hESC-derived striatal progenitors in the QA-lesion model
  
  P3.53 Nicolò Ricciardi (Palermo)
  Preventive effects of industrial lemon-derived nanovesicles on cognitive and dysmetabolic alterations in a high-fat diet rat model of metabolic syndrome
  
  P3.54 Martina Francesca Rizza (Pavia)
  Basket cell computational modeling predicts signal filtering of Purkinje cell responses
  
  P3.55 Anita Maria Rominto (Turin)
  Depression in mice causes decreased neuronal excitability and enhanced frequency adaptation in medial prefrontal cortex pyramidal neurons
  
  P3.56 Marta Russo (Rome)
  Morphological and molecular characterization of PC12 derived-dopaminergic neurons as cellular model of Parkinson’s disease
  
  P3.57 Giulio Sancini (Monza)
  The nasal route to the brain: brain’s physiology does make difference
  
  P3.58 Miriana Scordino (Palermo)
  Screening of novel metabotropic glutamate receptor 4-oriented molecules in an in vitro model of Parkinson’s disease
  
  P3.59 Leda Simeone (San Giovanni Rotondo, FG)
  Prion-like transmission of Alexander Disease mutant GFAP via tunneling nanotubes and extracellular vesicles
  
  P3.60 Giorgia Sollai (Cagliari)
  Threshold and perception intensity of different fatty acids in relation to olfactory function and sex
  
  P3.61 Paolo Spaiardi (Pavia)
  Transient capacitance changes recorded from vestibular type I hair cells are produced by G_K,L gating and do not involve neurotransmitter exocytosis
  
  P3.62 Cecilia Steinwurzel (Pisa)
  β-hydroxybutyrate enhances visual cortical excitability in humans
  
  P3.63 Beatrice Tranquilli (Rome)
  Environmentally relevant particulate matter concentrations affect neuron differentiation in in vitro model
  
  P3.64 Giulia Urone (Palermo)
  Staging temporal lobe epilepsy from molecular pathways to behavioral signatures in the pilocarpine-induced rat model
  
  

  Physiology of Metabolism

  P3.65 Giuliana La Rosa (Naples)
  Absence of Dipeptidyl peptidase 3 modulates Nrf2 pathway and autophagy/mitophagy machinery impairing osteoblast function under nutrient excess
  
  P3.66 Ciro Menale (Naples)
  Partitioned exogenous palmitate drives adipocyte hypertrophy by rewiring cellular metabolism and mitochondrial function.
  
  P3.67 Maria Teresa Muscari Tomajoli (Naples)
  Artificial light at night as a physiological stressor in freshwater amphipods
  
  P3.68 Martina Parente (Rome)
  Therapeutic potential of BET protein inhibition in Niemann-Pick type C1 disease
  
  P3.69 Maria Giovanna Rizzo (Messina)
  Lipogenesis, lipolysis, β-oxidation, and osteogenesis drive bone physiology in a 3D model
  
  P3.70 Simona Terzo (Palermo)
  Opuntia ficus indica fruit preserves cognitive function in obese mice through microbiota-dependent gene expression modulation
  
  P3.71 Giovanna Trinchese (Naples)
  Shaping fat: how supplementation of milk from different mammals influences brown and white adipose function in rats
  
  P3.72 Michela Vigliotti (Benevento)
  Reprogramming testicular mitochondrial homeostasis with T2 and T3 in high-fat diet rats